Possible mechanisms of spasmolytic action of bile salts on the isolated guinea-pig gallbladder.
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Possible Relaxant Effects of Thymoquinone on Guinea Pig Tracheal Chain
In the previous studies the relaxant, anti-cholinergic (functional antagonism) and anti-histaminic effects of Nigella sativa have been demonstrated on guinea pig tracheal chains. To elucidate the main substance responsible for the relaxant effect of this plant, the effect of thymoquinone, one of the main constituent of Nigella sativa was examined in this study. The bronchodilatory effects of th...
متن کامل[Sites of action of CCK of the guinea pig gallbladder].
Cholecystokinin-octapeptide (CCK-OP) evoked contraction and 3H-acetylcholine (3H-ACh) release of the muscle strip of the guinea pig gallbladder were studied. Although hexamethonium (10(-5) M) or tetrodotoxin (10(-6) M) had no effect on CCK-OP (10(-8) M) evoked contraction and 3H-ACh release, Ca-free medium almost completely abolished CCK-OP (10(-8) M) evoked 3H-ACh release. In Ca-free medium co...
متن کاملPossible Mechanism(s) of the Relaxant Effects of Achillea wilhelmsii on Guinea-Pig Tracheal Chains
Achillea wilhelmsii have been used in folk remedies. The relaxant effects of the extractof A. wilhelmsii on tracheal chains of guinea pigs were examined. The relaxant effects offour cumulative concentrations of the extract, theophylline and saline were examined bytheir relaxant effects on precontracted tracheal chains of guinea pig by KCl (group 1), 10 μMmethacholine (group 2), incubated tissue...
متن کاملPossible Mechanism(s) of the Relaxant Effects of Achillea wilhelmsii on Guinea-Pig Tracheal Chains
Achillea wilhelmsii have been used in folk remedies. The relaxant effects of the extractof A. wilhelmsii on tracheal chains of guinea pigs were examined. The relaxant effects offour cumulative concentrations of the extract, theophylline and saline were examined bytheir relaxant effects on precontracted tracheal chains of guinea pig by KCl (group 1), 10 μMmethacholine (group 2), incubated tissue...
متن کاملRelaxant effect of pioglitazone on the guinea-pig isolated trachea through the modulation of endogenous prostaglandins
Thiazolidinediones are commonly used anti-diabetic drugs. Owing to the anti-inflammatory action of TZDs as a result of there action on the PPAR gamma receptor and a proposed action on the prostaglandins, these drugs can be tried in the acute exacerbations of COPD that are also commonly found among diabetic patients. An experimental study of one week was carried out at animal house of Army Medic...
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ژورنال
عنوان ژورنال: Japanese Journal of Smooth Muscle Research
سال: 1990
ISSN: 0374-3527,1884-8788
DOI: 10.1540/jsmr1965.26.143